The Singapore General Hospital (SGH) Perioperative Center selectively participates in rigorous local and multicenter international trials that aim to improve patient outcomes.
Below are the trials that are currently ongoing:
1. Preoperative Anemia Among the Elderly Undergoing Major Abdominal Surgery (PANAMA): Impact on Healthcare Outcomes
ClinicalTrials.gov ID: NCT03497416
Preoperative anemia is a known risk factor for morbidity, mortality and increased healthcare resource utilisation. The main objective of this study single-centre prospective observational study is to investigate the perioperative morbidity and mortality, blood transfusion rate, healthcare outcomes and patient-centric outcomes among anemic elderly patients undergoing major surgery.
2. Preoperative Intravenous Iron Infusion to Reduce Post-surgical Complications: a Pilot Randomised Control Trial (PIRCAS)
ClinicalTrials.gov ID: NCT03295851
Preoperative anemia leads to increased rates of perioperative blood transfusion, mortality, adverse cardiac and non-cardiac complications. This study is a randomised, open-label study to investigate the efficacy of intravenous iron compared to oral iron in patients with anemia undergoing major surgery to reduce surgical complications.
3. The Impact of Prehabilitation Bundle on Perioperative Outcome for Frail Elderly Patients Undergoing Major Abdominal Surgery
ClinicalTrials.gov ID: NCT02921932
Frailty is a geriatric syndrome, defined as an increased vulnerability to stressors leading to a state of decreased physiological resistance. It is more prevalent among the older adult population and is associated with up to a threefold increased risk of mortality or major morbidity postsurgery. This prospective, single-centre, randomised controlled trial with two parallel arm study aims to evaluate the efficacy of a preoperative “bundle” of interventions, which consists of preoperative physiotherapy, nutritional support and cognitive exercises on elderly frail patients undergoing major abdominal surgery, and their postoperative outcomes.